Indian Journal of Human Genetics
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Year : 2013  |  Volume : 19  |  Issue : 4  |  Page : 459-464

Msx1 Gene Variant - its Association in Isolated Hypodontia: A Case Control Genetic study!!!

Department of Orthodontics, Academy of Medical Education's Dental College and Hospital, Raichur, Karnataka, India

Correspondence Address:
Rohra G Mayur
Department of Orthodontics and Dentofacial Orthopaedics, Academy of Medical Education's Dental College, Hospital and Research Center, Near Government Polytechnic College, Bijengere Road, Raichur - 584 103, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-6866.124376

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Introduction: Non-syndromic tooth agenesis is a congenital anomaly with significant medical, psychological, and social ramifications. There is sufficient evidence to hypothesize that locus for this condition can be identified by candidate genes. Aim of the Study: The aim of this study was to test whether MSX1 671 T > C gene variant was involved in etiology of non-syndromic tooth agenesis in Raichur patients. Materials and Methods: Blood samples were collected with informed consent from 50 subjects having non-syndromic tooth agenesis and 50 controls. Genomic deoxyribonucleic acid (DNA) was extracted from the blood samples, polymerase chain reaction (PCR) was performed, and restriction fragment length polymorphism (RFLP) was performed for digestion products that were evaluated. Results: The results showed positive correlation between MSX1671 T > C gene variant and non-syndromic tooth agenesis in Raichur patients. Conclusion: MSX1 671 T > C gene variant may be a good screening marker for non-syndromic tooth agenesis in Raichur patients.

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