Indian Journal of Human Genetics
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Year : 2013  |  Volume : 19  |  Issue : 4  |  Page : 465-468

Analysis of association of TaqI VDR gene polymorphism with the chronic periodontitis in Dravidian ethnicity

1 Department of Periodontics, Saveetha Dental College, Chennai, Tamil Nadu, India
2 Department of Genetics, ALMPGIBMS, Chennai, Tamil Nadu, India

Correspondence Address:
Gurumoorthy Kaarthikeyan
Department of Periodontics, Saveetha Dental College, 162, P.H. Road, Velappanchavadi, Chennai - 600 077, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-6866.124377

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Aim: The aim of this study is to analyze the association of TaqI vitamin D receptor (VDR) gene polymorphism with the chronic periodontitis (CP) in Dravidian ethnicity. Materials and Methods: A total of 120 subjects were recruited for this study, which included 60 CP and 60 healthy controls. TaqI VDR gene polymorphism was analyzed using specific primers and amplified by polymerase chain reaction (PCR) and visualized under 2% agarose gel. Results: Our study results showed that Tt and tt genotype had a higher frequency of occurrence in CP compared with controls. Similarly, t allele was found to be associated with CP. Conclusion: Our study concludes that TaqI VDR gene polymorphism is associated with CP in Dravidian ethnicity.

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