Table of Contents

February 2002; 2 (1)

Speaking of Pharmacology




  • Nuclear factor κB (NF-κB) regulates the transcription of a number of proinflammatory mediators. NF-κB turns out to be an important target of traditional anti-inflammatory agents (like aspirin), and has been singled out for targeting by a new generation of drugs.

  • Immune disorders that are supported by the action of cytokines are now giving way to novel therapeutics. The potential of biopharmaceuticals is transitioning into reality within the context of many diseases.

  • Silencing of the Reelin gene may contribute to the etiology of schizophrenia. Investigations of Reelin and of the epigenetic mechanisms that regulate neurodevelopmental genes may provide approaches to treating psychiatric illness.

Beyond the Bench