Table of Contents

April 2002; 2 (2)

Speaking of Pharmacology


Net Results


  • The nuclear transcription factors LXRα and LXRβ help to control circulating levels of fatty acids and cholesterol by stimulating the expression of genes associated with lipid and sterol modification, storage, and removal. Knowing how the expression and the activity of these transcription factors are regulated may aid in the development of treatments for disorders of lipid storage and elimination.

  • Although the Gα and the Gβγ subunits of heterotrimeric G proteins can effect different signaling processes in cells, the mechanisms that govern their different signaling outcomes have been underappreciated. GoLoco motif-containing proteins bind specifically to Gα loaded with GDP, and hinder Gβγ from re-associating to Gα. Thus, Gβγ-dependent signals may be sustained. Additionally, “GoLoco proteins” may have effector functions themselves, particularly in the regulation of cell division.

  • Just a few years ago, the amazing thing about microarrays was that they worked; today, microarrays astound with the detail of biomedical information they can provide. Breast cancer research is a prime example, where microarrays are helping to establish etiology, diagnosis, and treatment strategies.

Beyond the Bench