CaMKII, an Enzyme on the Move: Regulation of Temporospatial Localization

Mechanism for nuclear targeting of CaMKII. A. CaMKII isoforms that contain a nuclear localization sequence (NLS) target nuclear entry. The prototype NLS of SV40 T antigen is included for sequence comparison (21–23). B. The ratio of cytosolic isoform vs. nuclear isoform determines the subcellular localization of δ_B CaMKII (21). C. Phosphorylation close to the NLS by CaMKI or CaMKIV prevents nuclear entry of α_BCaMKII (23), whereas an increased level of PP2A was associated with nuclear targeting of δ_BCaMKII (91).