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CaMKII, an Enzyme on the Move: Regulation of Temporospatial Localization
Table 1.
Proteins that Interact with CaMKII
| Interacting protein | Interaction domain of CaMKII | Interaction domain of partner | Interaction inhibitor(s) | Interaction protein enhancer(s) | Function hypothesized by authors | References |
|---|---|---|---|---|---|---|
| CaMKII | Association domain | Association domain | Form CaMKII holoenzyme | (93, 94) | ||
| Catalytic domain | Regulatory domain | CaMKII autoregulatory domain inhibitor peptides: AC-2, AIP | Low pH, ATP, Ca2+-CaM | Sequester and inactivate α CaMKII in ischemia | (95, 96) | |
| α-actinin 1 | Catalytic and regulatory domains | EF hand-containing C-terminus | EDTA | Ca2+ | Modulate the association of α CaMKII with actin cytoskeleton and access to putative PSD substrates (GluR1, NR2A, NR2B) | (97) |
| α-actinin 4 | Kinase domain | EF hand-containing C-terminus | Tether α CaMKII to NMDA receptor complex at PSD | (65) | ||
| F-actin | Variable region of β CaMKII | CaM | Localize α CaMKII to dendritic spines via β CaMKII | (19) | ||
| Myosin-V | aa 760–1436 | Deliver myosin-bound CaM to activate CaMKII; Regulate organelle transport in mitosis | (42) | |||
| Synapsin I | Regulatory domain | C-terminus | Regulation of synaptic vesicle pools | (98) | ||
| Syntaxin 1A | Linker | EGTA PP1 activity Munc18 | CaMKII oligomerization and autophosphorylation (required) | Recruit SNAP-25 and Synaptotagmin for exocytosis in presynaptic terminals | (99) | |
| Synaptotagmin | EGTA Phosphatase activity | Ca2+ | Regulate SNARE complex/exocytosis in presynaptic terminals | (100) | ||
| Camguk | Regulatory domain | pT305 pT306 | Ca2+ AMP-PNP | Localize CaMKII and regulate its activity at in press synapses depending on local Ca2+ levels | Lu et al., | |
| PP2A | δB CaMKII | Catalytic subunit | Ca2+-induced cardiac hypertrophic response | (91) | ||
| NR1 | C-terminus | α-actinin 2 | pT286 | Recruit CaMKII to PSD | (84) | |
| NR2A | C-terminus, aa 1389–1464 | PSD-95 | pT286 | Recruit CaMKII to PSD and modulate channel activity for regulation of LTP and LTD of synaptic strength | (80, 101) | |
| NR2B | C-terminus, aa 839–1120 | pT286 | Recruit CaMKII to PSD and modulate channel activity for regulation of LTP and LTD of synaptic strength | (80, 81, 88) | ||
| C-terminus, aa 1259–1310 | Ca2+-CaM | |||||
| Eag K+ channel | Catalytic domain | C-terminus, aa 773–794 | Ca2+-CaM, pT286 | Scaffold and activate CaMKII | Sun et al. submitted | |
| L- type Ca2+ channel α1c | C-terminus | pT286 and/or Ca2+-CaM | Ca2+-dependent facilitation | (90) | ||
| Cdk5 activators p35, p39 | Catalytic and regulatory domains | C-terminal Cdk5 binding region | EDTA, EGTA, KN62, KN93, MK801(major) CNQX (minor) | Ca2+ Glu–Gly | Enhance Cdk5 localization to putative PSD substrates | (97) |
| SynGAP-β | C-terminus | pT286 | Recruit and anchor nonphosphorylated CaMKII to PSD | (102) | ||
| Densin-180 | Association domain | C-terminus | pT286 | Recruit and anchor CaMKII to PSD | (38, 65) | |
| α KAP | Association domain | Direct CaMKII to the sarcoplasmic reticulum in skeletal muscle | (47, 48) | |||
| Karyopherin/Importin | NLS in variable region of αB and δB CaMKII | Phosphorylation by CaMKIV and CaMKI | Target CaMKII to nucleus for regulation of gene expression | (23) | ||
| Tubulin | Bind CaMKII to the cytoskeleton | (103) | ||||
| β 1 Integrin | Modulation of β 1 integrin association with the actin cytoskeleton | (104) | ||||
| Rad GTPase | Modulation of rad function | (105) | ||||
| Projectin | pT286 | Activate CaMKII activity w/o CaM in muscle | (106) | |||
| CaM-KIIN | Catalytic domain | C-terminus, aa 43–69 | CaMKII inhibitor | (107) | ||
| Raf-1 | KN93 | Integrin activation | Regulation of ERK signaling | (108) |
