Designing Immunotherapies to Thwart Drug Abuse

Immunoglobulin (IgG) antibody and functional fragments. The ovals represent immunoglobulin folding domains, with corresponding abbreviations: VL, variable domain light chain; VH variable domain heavy chain; CL constant domain light chain; CH, constant domain heavy chain. The polypeptide linker of the scFv is represented by a blue connecting ribbon. The dendribody is represented by a branched structure (dendrimer) with multiple scFv attached. The linker has been omitted from the scFvs of the dendribody for clarity. Figure adapted from (47) and used with kind permission of Springer Science+Business Media.