HETEROCYCLES
An International Journal for Reviews and Communications in Heterocyclic ChemistryWeb Edition ISSN: 1881-0942
Published online by The Japan Institute of Heterocyclic Chemistry
Special Issue
Alan R. Katritzky's Special Issues, Vol. 37, No. 2, 1994
Published online:
■ Synthesis and Reactions of Lithiated Monocyclic Azoles Containing Two or More Hetero-Atoms. Part I: Isoxazoles
Brian Iddon*
*The Ramage Laboratories, Department of Chemistry and Applied Chemistry, University of Salford, Salford M5 4WT, U.K.
Abstract
The metallation and halogen → metal exchange reactions of isoxazoles (1,2-oxazoles) and the reactions of the resulting organometallic derivatives, particularly lithiated derivatives, are reviewed comprehensively.
Published online:
■ Synthesis and Reactions of Lithiated Monocyclic Azoles Containing Two or More Hetero-Atoms. Part II: Oxazoles
Brian Iddon*
*The Ramage Laboratories, Department of Chemistry and Applied Chemistry, University of Salford, Salford M5 4WT, U.K.
Abstract
The metallation and halogen → metal exchange reactions of oxazoles (1,3-axazoles) and the reactions of the resulting organometallic derivatives, particularly lifhiated derivatives, are reviewed comprehensively.
Published online:
■ Extension of Decker Oxidation
Josef Kuthan*
*Department of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague, Technická 5, Czech Republic
Abstract
Ferricyanide oxidation of 1-substituted 2,4,6-triaryl-, 2,3,4,6-tetraaryl- and 2,3,4,5,6-pentaarylpyridinium salts has been found to be a general approach to the synthesis of substituted pyrroles and/or imidazoheteroaromatics. The regio- and stereoselectivities of the oxidative transformations as well as their possible mechanisms are discussed.
Published online:
■ Small Ring Compounds Containing Sulfur Atoms
Shigeru Oae*
*Inatitute of Heteroatom Chemistry, 25009 Hirao, Mihara-cho, Minamilawachi-gun, Osaka 587, Japam
Abstract
Small ring compounds containing sulfur atoms, especially three and four membered heterocycles, were reviewed in the light of recent findings and hypotheses.
Published online:
■ Contributions of Molecular Orbitals Techniques to the Study of Dihydropyridines
Marcus E. Brewster,* Emil Pop, Ming-Ju Huang, and Nicholas Bodor*
*The College od Pharmacy, Center for Drug Discovery, JHMHC, Box 100497, University of Florida, Gainesville, FL 32610, U.S.A.
Abstract
The discovery that dihydropyridines constitute the operational subunits in important coenzymes such as NAD(P)H has directed major research efforts at understanding the redox chemistry of these heterocycles. Molecular orbital approaches have been extremely useful in this regard. This short review is designed to survey the application of semiempirical and ab initio techniques to the study of mechanisms of dihydropyridine oxidation, transition state structure and the mechanisms thought responsible for stereospecificity of enzymatic oxidoreductions which utilize NAD(P)H as a coenzyme.
Published online:
■ Heteroaromatic-fused 3-Sulfolenes
Kaori Ando* and Hiroaki Takayama*
*College of Education, University of Ryukyus, Nishihara-cho, Okinawa 903-01, Japan
Abstract
This review deals with our recent works1 on the preparation of heteroaromatic-fused 3-sulfolenes (5) and their chemistry, especially Diels-Alder reactions with several dienophiles under thermal or high pressure conditions. Related chemistry of the positional isomers (6) is also reviewed.